Gilvusmycin, a new antitumor antibiotic related to CC-1065.
نویسندگان
چکیده
A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.
منابع مشابه
The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.
The structure of CC-1065 (Fig. 1) was determined by X-ray crystallography5,6). Prior to isolation of a suitable crystalline form of CC-1065 for X-ray diffraction data collection, a chemical degradation product (1) obtained by reaction of CC-1065 with ethyl isocyanate in pyridine was crystallized and its structure determined by X-ray crystallography". A closely related compound, PDE I (2), was p...
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CC-1065 (NSC 298223), a potent new antitumor antibiotic produced by Streptomyces zelensis, interacts strongly with double-stranded DNA and appears to exert its cytotoxic effects through disruption of DNA synthesis. We undertook this study to elucidate the sites and mechanisms of CC-1065 interaction with DNA. The binding of CC-1065 to synthetic and native DNA was examined by differential circula...
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متن کاملCC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 52 3 شماره
صفحات -
تاریخ انتشار 1999